![]() The most promising therapies with the highest quality data include diphenylcyclopropenone, squaric acid dibutylester, photodynamic therapy, steroids, and cyclosporine in combination with methylprednisolone. To avoid the side-effects caused by corticosteroids, we evaluated the efficacy and safety of LD-MTX alone in AA resistant to several conventional therapies. Alopecia universalis was seen in a 70-year-old male on day 20 of daily treatment with albendazole 15 mg/kg/day for Echinococcus.Alopecia fully recovered 1 month after stopping the medication 10 c. The most promising therapies with the highest quality data include diphenylcyclopropenone, squaric acid dibutylester, photodynamic therapy, steroids, and cyclosporine in combination with methylprednisolone. Although certain treatments showed significant hair regrowth, no treatment was completely effective. Systemic corticosteroids is effective in treating AA but side-effects during long-term therapy and relapse after dose reduction or withdrawal have restricted their use 17. Usually, telogen effluvium is caused by physical or mental stress, such as severe illness, surgery, childbirth, emotionally stressful events, extreme diets, and medications. There are several reports using MTX in AA with systemic corticosteroids to increase the therapeutic efficacy 13 14 16. Oral dexamethasone afforded a similar response rate (37%) in AA patients, although relapse was frequent (74%) and adverse events were more common (30%) 15. In this article we will cover the most prominent therapeutic candidates in the alopecia areata treatment industry in 2023. Some people may regrow hair, while others do not.4 Hair regrowth can be spontaneous,10 or it can happen following treatment.11. ![]() 14 also reported a 50% complete response using combination therapy with a high-dose pulse corticosteroid and MTX, although it was less effective in children. Chartaux and Joly 13 reported complete regrowth in 57% of the patients treated with MTX alone. This result is similar to those of previous studies. Alopecia areata (AA) is a chronic, autoimmune disorder of non-scarring hair loss mediated by T-lymphocytes against the hair follicular unit. In this study, we showed that LD-MTX is a useful treatment option for intractable AA multiplex.
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